jkimmel
Joined 14 years ago
Karma
917
Submissions
151
Member since
Jun 1
Recent submissions
Comment · 6 years ago
Overleaf is one of my favorite tools. Thanks for building such a wonderful product!
Comment · 6 years ago
Notion thankfully does support LaTeX, but only in equation mode (e.g. `\[...\]`, not `\(...\)`).
Just type `/math` in a Notion document to bring it up.
Comment · 7 years ago
The book "Pacific" by Simon Winchester has an educational description of this event, contextualized in the broader story of how the DMZ came to be.
Comment · 8 years ago
France already has multiple unmanned subway lines that manage to do okay. My bet is cameras and a non-trivial chance of vandals getting stopped at the next station would be sufficient protection against this.
Comment · 9 years ago
> even going so far as to pay a nanny
I really like this idea as a way to expand access to startup opportunities.
Have any acceleartors/incubators experimented with offering child care? I imagine that economies of scale could make that more economical than having X% of each investment go to child care with no coordination, even if it was just a group-rate contract with a local child care center.
Comment · 9 years ago
There were several bills in the CA Leg this year that passed thanks in large part to YIMBY support.
See:
SB2 - Subsidized housing bond
SB35 - Streamlining construction
SB167 - Housing Accountability Act enforcement, written with help from YIBMY affiliate CARLA (carlaef.org)
http://www.sacbee.com/news/politics-government/capitol-alert...
Comment · 9 years ago
Sanders proposed a prize system for pharmaceuticals. It's an interesting alternative to patents for rewarding innovation in that space particularly, which is entirely patent dependent.
Comment · 9 years ago
This is definitely an Umami Burger problem. I've had it there and at Cockscomb down the block, and it's infinitely better at the latter location.
Comment · 9 years ago
As a former Orlandoan, I would pull Orlando from that list based on public transit.
Transit in Central Florida is basically non-functional, and not likely to change anytime soon. The region is entirely car-centric, and there is a strong cultural bias against public infrastructure of any kind.
You can surely look up a map with lots of bus lines drawn across the Orlando core (Lynx), but the service is so remarkably horrific, I never met anyone who used Lynx in the 21 years I lived in the region.
Comment · 9 years ago
Likewise for SF, their estimate is $1250/month, which will rent you a garage or a converted living room with a curtain separating it from the kitchen in the far reaches of the city.
As a grad student, this is about my budget for housing, and I promise you I'm not exaggerating.
Comment · 9 years ago
> Short of a drug that provided a permanent cure for opioid addiction itself, I'm not sure what sort of solutions can be pursued by scientific/tech research, as opposed to addressing the root social causes.
People have actually been trying vaccine approaches to opioid addiction for a while, but it's tricky since opioids are small molecules which inherently don't give you a lot to work with as far as antigen presentation.
Apparently there has been some promising evidence recently though. See Derek Lowe's blog below for details.
http://blogs.sciencemag.org/pipeline/archives/2017/06/26/a-h...
Comment · 9 years ago
There's no reason storing information in a population of DNA molecules is fundamentally unstable.
Yes, mutations occur. Randomly. This means that if you sequence a set of DNA molecules the consensus sequence can still render the proper data string despite flaws in each individual copy.
In the context of generating organisms like this, so long as your stored information is not in a loci that could be mutated to regulate proliferation in a positive way, mutations in your storage string wouldn't propagate in a consensus manner (in some organisms, it's hard to make them grow faster. E. coli for instance have already been optimized to divide pretty darn quickly by evolution).
The same is true for populations of DNA molecules rather than organisms (are any organisms much more than DNA storage and maintenance machines :-D?). Random mutations in one molecule in a tube would be different for each neighboring molecule, but the consensus sequence is still valid.
This all makes perfect intuitive sense when you recognize that even some DNA sequences with no positive effect on growth are fairly well conserved on evolutionary timescales. https://www.wikiwand.com/en/Long_terminal_repeat https://www.wikiwand.com/en/Alu_element
Comment · 9 years ago
There is a set of assumptions in your argument that I believe are false.
1. Unregulated water use that allows for production of export cash crops will continue
This could easily be fixed by regulating water use properly, such that farmers have economic incentive to grow crops that are less water intensive given that CA is not water rich.
2. Market prices of current export and current import crops will hold constant regardless of growth
That's not how markets work.
If there was a sudden surge in lettuce demand, farmers in Salinas would respond to increasing prices by switching some fields currently used for export crops to lettuce, which would be consumed locally.
This is aided by point (1) above, where we could push this shift with water regulations.
On the whole -- your concerns seem best addressed by sensible regulation of water in CA, which is a long term political problem. Opposing the farm lobby is well known third rail in the CA Leg.
Nativist population control programs are not the solution to a market failure of water distribution, however they might be implemented. Opposing housing construction is even a really poor way to implement a nativist population control program.
Co-founder & Head of Research at NewLimit. Previously Principal Investigator at Calico, PhD at UCSF.
If you're in town, feel free to shoot me an email to chat about how cells work, aging research, the life sciences, startups, or the local coffee shop landscape. I'm always looking to learn from interesting people.
@jacobkimmel on Twitter et. al.
[email protected]