iso1337
Joined 11 years ago
Joined 11 years ago
I find there’s a ton of slop unless hard guardrails are added, eg step 1 is just around syntax, step 2 is to enforce mental models
You still need someone steering direction and have a logically consistent idea of what you actually want to build
Q2 - I find that vibe coding really accelerates FE projects because it’s possible to run everything locally and check results
For pure distributed infra backend more investments have to be made into the devloop to be able to shift left the feedback loop and decouple it from humans or real deploys
Eg UI cannot reach down and directly read config files
Configs must be only read by (im assuming) a storage interface layer called repo
There’s a strict directionality of dependency
Somewhat similar to ports and adaptors but presumably more strictly enforced by deterministic linters
It will also tilt more senators/congresspeople to vote for NIH funding, similar to military base funding
https://news.ycombinator.com/item?id=13768856
The spirit of the law is good, but sometimes it just means that we lose "good enough" in pursuit of "perfect".
"Additionally, because the final product does not have a Type IIS restriction enzyme recognition site, the correctly-ligated product cannot be cut again by the restriction enzyme, meaning the reaction is essentially irreversible"
https://en.wikipedia.org/wiki/Golden_Gate_Cloning ----
The choice of focusing on a particular RE pair also smells of p-hacking. Their claim that BsaI/BsmBI makes for easy mixing/matching genomes doesn't make sense in this day and age, when you can use other techniques to make hybrids more effectively (eg, you are not restricted to the natural location of those restriction enzyme sites)
Synthetic biology (the actual synthesis of DNA) has come a long way, we don't understand all the components yet though.
In general, Americans don't want to pay a huge cost upfront for some efficiency gains. Especially since traditionally fossil energy was cheap.
Also look at heat pump clothes dryers. They're a win in that you don't need a vent (and associated vent cleaning), but they cost more upfront.
Hopefully these are areas where the government can provide low interest rate loans upfront, since they are investments that pay for themselves over time.
Does GM have any competency in this area?
Use the carrot and the stick to incentivize a healthier mode of transportation.
Forcing parents to have disabled kids is not good policy either.
Your local restaurant with thin margins and underpaid staff is an SME