Recent submissions

Comment · 4 months ago
A lot of jobs are at SMEs but they’re low quality service jobs…

Your local restaurant with thin margins and underpaid staff is an SME

Comment · 4 months ago
Q1 - How much effort did you put into deterministic guardrails like AST linters, etc?

I find there’s a ton of slop unless hard guardrails are added, eg step 1 is just around syntax, step 2 is to enforce mental models

You still need someone steering direction and have a logically consistent idea of what you actually want to build

Q2 - I find that vibe coding really accelerates FE projects because it’s possible to run everything locally and check results

For pure distributed infra backend more investments have to be made into the devloop to be able to shift left the feedback loop and decouple it from humans or real deploys

Comment · 4 months ago
IIUC its just strict separation of concerns

Eg UI cannot reach down and directly read config files

Configs must be only read by (im assuming) a storage interface layer called repo

There’s a strict directionality of dependency

Somewhat similar to ports and adaptors but presumably more strictly enforced by deterministic linters

Comment · 3 years ago
NIH should build more institutes in cheaper areas (eg not NoVa). It’s a win win since it will help revitalize poorer areas of America and save on costs.

It will also tilt more senators/congresspeople to vote for NIH funding, similar to military base funding

Comment · 4 years ago
And that's why a ton of video lectures from UC Berkeley had to be taken down due to lack of captions.

https://news.ycombinator.com/item?id=13768856

The spirit of the law is good, but sometimes it just means that we lose "good enough" in pursuit of "perfect".

Comment · 4 years ago
Any publicity is good publicity. Sprinkle in some words about "this needs further study" and hope someone comes along to fund the next few years of your lab.
Comment · 4 years ago
Their claims around Type IIS assembly are also suspect. eg in Golden Gate assembly, you choose Type IIS that reach over and cut, so the restriction site is absent from the final assembled product.

"Additionally, because the final product does not have a Type IIS restriction enzyme recognition site, the correctly-ligated product cannot be cut again by the restriction enzyme, meaning the reaction is essentially irreversible"

https://en.wikipedia.org/wiki/Golden_Gate_Cloning ----

The choice of focusing on a particular RE pair also smells of p-hacking. Their claim that BsaI/BsmBI makes for easy mixing/matching genomes doesn't make sense in this day and age, when you can use other techniques to make hybrids more effectively (eg, you are not restricted to the natural location of those restriction enzyme sites)

Comment · 4 years ago
There is a huge variety of viruses, just because someone wrote the equivalent of "Hello World" doesn't mean you can write a complicated CMS anytime soon.

Synthetic biology (the actual synthesis of DNA) has come a long way, we don't understand all the components yet though.

Comment · 4 years ago
https://dandelionenergy.com/ is one company trying to scale this.

In general, Americans don't want to pay a huge cost upfront for some efficiency gains. Especially since traditionally fossil energy was cheap.

Also look at heat pump clothes dryers. They're a win in that you don't need a vent (and associated vent cleaning), but they cost more upfront.

Hopefully these are areas where the government can provide low interest rate loans upfront, since they are investments that pay for themselves over time.

Comment · 4 years ago
LFP batteries are the future for home energy storage. Less fire risk, cheaper. They're heavier, but that's totally fine for a stationary application.

Does GM have any competency in this area?

Comment · 4 years ago
The fact that white is the default is already problematic.
Comment · 4 years ago
I think so many of these issues can be solved by going on road diets and dedicating an entire car lane to bikes.

Use the carrot and the stick to incentivize a healthier mode of transportation.

Comment · 4 years ago
I don’t know if you have relatives or children with Down’s, but it is no walk in the park.

Forcing parents to have disabled kids is not good policy either.

Comment · 4 years ago
Instagram is one of the few platforms that allows you to comment on ads. It's pretty interesting as the comments tend to be overwhelmingly negative.

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