glp1guide

This is a fantastic idea and could do a lot of real good. Any plans to get your hands on a distribution agreement for small molecule or peptide oral formulations?

I write a GLP1 newsletter and would love to learn more about what you’re building and how you see the landscape.

Reta looks like it will make it out by early next year but I personally think they’ll squeeze in to end of this year — there will likely never be a undersupply of GLP1s again and I wonder if the customization loopholes will hold (Lilly will certainly fight Reta compounders harder than they have others), interested to hear your thoughts and chat.

I keep track of GLP1s and write a lot about them (looking for negative side effects, research results, etc) and it is amazing how potent retatrutide is. It’s not simply a matter of “more agonists, more better” but it looks like Eli Lilly has really cracked it.

There is a large enthusiast community of the body building variety (who are usually first) who are already performing a bit of an unscheduled human trial and I have to say the results are amazing. We have both injectable retatrutide and pill form retatrutide to look forward to (pill form is unannounced but I have a hunch!).

Just stating the obvious -- losing weight (and likely lowering HbA1c/having other benefits) for 18 months is probably infinitely better than never losing weight at all.

Like others have mentioned, liraglutide already exists as a generic! It's not as good as Semaglutide or Tirzepatide, but.

Also, a lot of people are still getting compounded GLP1, to the chagrin of Eli Lilly and Novo Nordisk.

Separately, 2026 is about to completely change the pricing of this stuff, not even taking into account the Trump administration's recent efforts. The price of injected GLP1 is going to implode due to patents lapsing in Canada and other places -- and for the pill forms that come out soon it looks like the Trump administration is keen on keeping prices for that low as well.

At this point most experts lean more heavily on the effect of GLP1s in the brain rather than delayed gastric emptying -- it's more of a brain drug than anything else which is why it works so well.

Basically, the gastro-intestinal side effects are the biggest issue, along with CVS (not the store) and possibly eye problems.

That said, the negative side effects look to be incredibly rare and manageable (including via stopping treatment) -- and the positives are quite tremendous.

It's not a magic drug, but it is the first of it's kind with such a skew to the positive on side effects.

A bit late, but thanks for noting this -- I had no idea that this workaround was so well established. I don't often dive into concrete suggestions on how to obtain GLP1s because of how it could be perceived, but maybe I've underestimated how many people know how to do this right now.

Absolutely -- certainly in their biggest markets they'll be able to protect those patents.

Both companies have thus far been unable to really stop compounding pharmacies and/or gray market suppliers from replicating though, and price negotiation with the government is definitely going to happen (Trump recently announced wanting $150 GLP1s, Novo's lawsuit against medicare price negotiation failed)... I do not have much faith in their ability to protect their pricing power for very long, which unfortunate for them is probably what's best for humanity and is very well known at this point.

That sounds like a terrible experience, sorry you and the wife went through that and somehow the negative side effects STILL persist. This is honestly the first case I’ve ever heard of such an adverse effect.

GLP1s are certainly not for everyone, and if she had that reaction on a starting dosage then it certainly is obvious stopping was the way to go.

That said, for the vast majority of people though, GLP1s are likely going to the key to living longer and carrying less weight (including into old age). At this point, the research is behind the drugs being useful for the vast majority of the population, and the literal millions of people taking these drugs do not seem to be running into such horrific side effects, especially ones that continue after stopping the drugs.

Would you mind sharing which GLP1 she was on? This actually sounds like something that should be more widely known. Throwing up forever is quite a crippling side effect, and since GLP1s are more recently considered primarily brain drugs, I wonder if it triggered a persistent chemical imbalance.