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Cardiology fellow here. The more you have to pace the shorter the battery lasts? Struggling to see what the novelty is here.

People have been doing this for literally decades. Check out work by Tattonetti

This is most likely a good thing. It isn't killing cardiac myocytes, it's probably assisting with reverse remodeling. Fits with why we know it helps in heart failure.

You have no idea how a hospital or modern medicine works. It needs to be online.

Because essentially every large hospital in the USA does?

None of these works nearly as well as angioplasty

Just wrong. Read about the 7J7. The 787 cost something north of 20 billion to develop. The clean sheet 737 would have cost much more in today’s dollars. Boeing makes an average of less than 5% profit margin from the 1970s to now. It was a relatively obvious financial decision from Boeing’s perspective.

Shame on you.

We will not have supersonic transport for average people unless outsiders do it first. There are only two meaningfully large manufacturers now, Airbus and Boeing.

Boeing and Airbus both cannot financially afford a technologically promising but possible failure now. Boeing built the 737 MAXX because they couldn’t afford a clean sheet update of 70-year old technology despite the savings. Airbus lost almost as much as the entire company was worth on the A380, kept afloat by EU subsidies.

All new technology happens for the wealthy first - we would not have smartphones today if Apple was forced to price them at the median price of cell phones in 2004.

This has been beaten to death in high quality randomized controlled trials in sepsis. Don’t believe a university press release lol. HN is a pretty poor source of health information overall.

This is a simplification. For example niacin (vitamin B3) excesses cause cholesterol to become more atherogenic. And supplementation in patients without deficiency is ultimately harmful.

Your pancreas actually does know things like that you've ingested a lot of carbohydrates before they enter the bloodstream, etc. Certainly there is also a response to exercise that occurs before you coiod easily detect it with a CGM. There are very complex brain-gut-pancreas interactions mediated by a variety of molecules/hormones.

> Hypoglycemia becomes symptomatic long before blood sugar is low enough to result in death or serious debilitation and T1D patients know their symptoms well.

Often times in an acute setting, yes. However patients who have had diabetes (T1 or T2) for a long time often lose a lot of their hypoglycemia sensitivity and symptoms. It's not nearly that simple.

I believe that most of the lead used today is a by-product or co-product of mining other more valuable metals like Zinc and silver. Lead is quite abundant in the Earth's crust and found in easy to access deposits.

I think >80% of the current industrial use of lead is for batteries. It's probably still in the top ten most mined metals by dollar value and definitely by mass.

Fascinating. Thank you for sharing. I’m glad you were able to arrive at a diagnosis. I’m sorry to hear it was such an odyssey. I wonder how many other patients like you we are missing.

Thanks for sharing. I’m a doctor. If you don’t mind sharing, out of curiosity how were you diagnosed with this? Not one of the primary immunodeficiencies I see tested, but I’m not a medical geneticist or pediatrician.