dillydogg

This is how I interpret headphones in/on people's ears. I live in a mid-sized town in the US and I swear it's over 80% of people I see walking through the forest trail system have headphones in. I wave and say hello to everyone without headphones. I find it bizarre how many people go outside and walk in the forest just to block out the natural sounds. Or how everyone in the grocery store has them in. I feel like I'm surrounded by androids without an interest in human interaction. Or maybe more generally, I'm suspicious of the impulse to always have something to listen to, like music, a podcast, or an audiobook. Oh well, I suspect I'm just being an old man. I'm glad they have found a way to make going out more enjoyable.

Keep hoping!

Can you more accurately translate this to English for us?

What I would suggest as a pathologist who deals with diagnosing these: the incidence of differences of sexual development is somewhere between 1 in 1000 - 4500 births. So this policy will not unlikely diagnose someone with a DSD who didn't know.

These are pretty common, physiologic structures associated with infections. They can be just a handful of cells on a slide or be quite large, and I don't know what they found in these infections. I didn't read the original paper. The ectopic lymphoid structures go away after the infection resolves. It seems that the immune system has ways to set up mini lymph node architecture right by the site of infections, which is very sensible. The same process is going on in a more organized way in the draining lymph node in parallel. Research into these was really hot in the 2010s, but people don't seem to be as into them anymore (but my research has also transitioned to innate immunity from adaptive, so it's likely that I'm no longer in that universe).

In general, it doesn't surprise me that when you prime the innate immune system, the adaptive immune system works well. The problem is that pathogens have an incredible suite of tools ready to evade these mechanisms. The doses of the pathogens are typically insanely high too, which I do not think model natural infections well. Anyways, this is intriguing, so I'll take a look at the original paper one of these days. Vaccine research generally is so boring. It's like, we vaccinated, and it worked, or didn't, no mechanism.

I have noticed something similar. With the computer science undergrads and grad students I work with, Air is much more common than with the premeds and med students, many of whom have MBPs (who I am presuming do not need that much power).

I thought about defining it up front but decided to move it to the second paragraph.

I would say it's worth talking to a doctor about how you feel. There are many things that can help. If you are in the USA, if is likely that they will use the PHQ-9 form, so consider looking at that questionaire to see how it aligns with your mood. medcalc is a common site that many of the residents at my institution use for these questionaires and other various scoring systems.

I was taught that it was more a memory device for recognizing major depressive disorder as a state of sadness and low energy. The treatment, I presume was still SSRIs first line.

It's true. You wouldn't believe how many people I've SIGECAPS'd during my medical training. I didn't realize this article was the beginning of this approach, but it certainly helped get care to people who previously wouldn't have received it. Though I'm sure there are also many who may require intervention that aren't captured by a SIGECAPS exam. The double edged sword of the checklist manifesto, though I overall think it has been beneficial.

SIGECAPS is an acronym taught in US medicine for the diagnosis of major depressive disorder: Sleep disturbance, Interest loss, Guilt, Energy loss, Concentration loss, Appetite changes, Psychomotor agitation, Suicidality. And must have Depressed mood or Anhedonia (inability to enjoy things previously enjoyable).

The history of the SIG E CAPS acronym is also interesting, I've heard it was short for SIG (old shorthand for "to be prescribed") Energy CAPsules.

That's interesting because rodents and apes share a more recent common ancestor (75Mya) than dogs and apes (85 Mya).

It is a good point. It depends on how regressive is defined. There are many competing arguments here, but two I am aware of are

1. Regressive deals with % of income spent.

2. Regressive deals with an ideal state where those with more excess income contribute more than those with less.

In both of these, I suppose sales tax is regressive if it applies to all items, but only 2 is regressive with sophisticated rebates and untaxed categories.

It's funny, because sales tax is considered among the most regressive form of taxation we employ from my understanding, which is supported by my econ friends. But I'm certainly not an economist.

I suspect if what has transpired doesn't make them concerned, they will only be emboldened.