davecap1

There's a lot more to protein sequences than legos. I think the argument is that you don't need to train a model on fundamental organic chemistry/biochemistry, electrostatic protein interaction, hydrogen bonding, hydrophobic interaction, quantum mechanics, etc... in order for it to accurately predict protein sequences.

We have federated login with MFA required (which was failing). It just started working again.

Scratch that... console is not loading at all now :)

On top of that, the "Personalized Health Dashboard" doesn't work because I can't seem to log in to the console.

It's been 80 years and we still haven't figured out how to reliably perform loading doses (when someone is just starting out on warfarin) and to maintain stable INR (anticoagulation effectiveness, essentially) in people who take it daily. Lots of work has been done on it, but it is petering out due to the recent introduction of new anticoagulation drugs that do not require regular monitoring.

I happen to take warfarin daily, happy to answer any questions!

Interesting way of describing/thinking about hazard or risk analysis which is applied in many industries through ISO standard frameworks such as ISO 14971 for medical devices (but is also used elsewhere). Risk analysis complements requirements analysis in that risk mitigation plans become requirements of the system (if the risks meet some threshold).

Apple Health and Activity also seem to work this way, although they also sync to iCloud.

Have you thought about hiring someone remote in the same or different timezone to be on-call for outages? I'm sure there are many people around that would be able to help with this. You could hire someone on a retainer who can be on-call via PagerDuty or something.

23andMe only tests for known relatively common mutations (single nucleotide polymorphisms, or SNPs) that have been identified by non-profit large scale sequencing projects done in the past (basically public data now, see dbSNP for instance). You will almost certainly have mutations that are not covered by their panel, so it is not a matter of comparing your 23andMe results to the "baseline" (or "reference genome"). Their panel costs in the hundreds of dollars to run since it is so focused (at least 10x less than a full "exome" test, which would look at the full sequence of all known genes).

These are quite difficult to get (and very expensive to produce) even inside the medical-research establishment. Which big players are you referring to?

There are other mail clients that use tracking pixels, like Polymail and Canary.