cknoxrun

Joined 12 years ago

Karma
512
Submissions
150
Member since
Oct 2
CTO at DrugBank (www.drugbank.com), the worlds largest database on Drugs and Drug Targets.
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Recent submissions

Comment · 17 days ago
I ended up in the hospital after walking by my roommate who was washing off a knife with peanut butter on it in hot water in the sink. I just inhaled a single breath of steam and in minutes I couldn't breathe!
Comment · 17 days ago
I personally have definitely had a reaction from kissing someone after they ate peanuts, just not full-blown anaphylaxis.
Comment · 27 days ago
I got "Marmalade" in Claude (Opus 5.5)
Comment · 1 month ago
They have also been slowly, but surely, moving all their vehicles to HEV/PHEVs (at least in Canada). For example, you can only buy a new Camry, Sienna or Rav-4 (most popular SUV in the world) in hybrid/PHEV form.
Comment · 5 months ago
Google is actively, and directly helping companies continuously train use-case specific models based on Gemma 4 foundation. The company gets a model they fully own, trained on internal, sensitive data, and Google scoops up the profits from the training and ongoing compute spend to keep the model up-to-date.
Comment · 5 months ago
The interesting part is that agents are good at adding the safety layers (type safety) that exist for Ruby, but which add developer/cognitive overhead (such as Sorbet).

I actually find, for some reason, that LLMs seem to be able to be more "creative" when it comes to Ruby (having used LLMs across 4-5 languages). I don't mean hallucinating, but crafting solutions I would not have thought of, even if I've ensured that I've inserted my original thinking at the beginning.

I wonder if there is something about the combination of the expressiveness of Ruby and the way LLMs are closely tied to human language that brings that out. Of course, usual caveat: n of 1 on my own experience, and a dose of bias.

Comment · 5 months ago
I'm not sure where the original poster is from, but where I'm at (Canada) my local library has a large gaming collection, including Switch 2 games. The bigger games you have to wait a while on the hold list, but there are plenty of games available at any time, for free.
Comment · 7 months ago
Thanks for the clarification, I see where you are coming from and definitely agree it's a real problem.

I'm proud to say for myself that devices never leave the home now (and mine stays in my pocket except for explicit communication needs), and we are able to fully connect on road trips, dinners, and other outings. It's freeing, and I always tell the kids, that being device free means we will actually remember these moments.

Comment · 7 months ago
The only thing I'll add is that you never know what people are going through. Both of my children have pretty intense ADHD, and when I went through my divorce I definitely leaned into too much screen time for a while. It wasn't permanent though, and I managed to get back closer to the ideal you speak of (but as a single parent, it took a lot of processing of guilt to find a balance that worked).

I've decided it's safer to just never judge, that parent you see pushing the toddler around in the cart might indeed be a terrible parent, or they might be going through grief and at their breaking point.

Comment · 9 months ago
Coming from another stressed out startup CTO, I'm curious what your daily meditation routine look like now?
Comment · 2 years ago
I do like the approach Basecamp took to Kanban ("Card Table") - very very simple and clean (https://basecamp.com/features/card-table). We moved off of Basecamp but we found it super effective when we were a smaller team.
Comment · 4 years ago
Only things he has asked for, this is not driven by a need for academic improvement or anything, but a chance to learn tools to improve a known deficit with ADHD that can negatively impact his ability to maintain social connections.
Comment · 4 years ago
Interesting. I've often considered an Apple Watch for my 9 year old, who struggles with (and benefits from) ADHD and thus would benefit from specific features such as the reminders (especially location-specific), alarms, and overall organization capabilities. But I'm hesitant to open that box just yet...

He isn't pining for a smart phone yet, nor do his friends seem to generally own them, so that wouldn't be the motivation but I can understand how it would be a good intermediate step. Gradually increasing access to these technologies and educating them along the way makes sense to me, rather than passing the child the firehose when they turn a certain magical age.

Comment · 4 years ago
Not the greatest UI, but you can show 2 conversations at the same time by command-clicking on a person/channel (or right clicking on a second person/channel and choose "Open in split view").
Comment · 4 years ago
Your question caused a likely ludicrous and unoriginal idea to pop into my head - I wonder if it would be possible to purposefully engineer and release a mutated form of a virus like SARS-CoV-2 that demonstrates the ability to replace more dangerous strains, but causes only mild symptoms? Essentially to accelerate a process that we hope to see happen naturally.

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