cixin

A bit weird but they also used to do "Service Packs" which seemed reasonable. Do they still plan to do service packs or this the new way forward?

The approach is interesting, but I'm not sure it works for everybody. I tried the Heisig method, but I found that while I could get good at flashcards, they didn't really stick.

Probably helps if you are also exposed to Kanji on a daily basis in their true context.

Off the top of my head: I wonder if astronauts are on lower calorie diets than usual.

Lowering calorie intake is one of the few well known ways that lifespan can be increased. Will have to see if there's any research correlating low calorie diets and telomere length.

Yes mostly the number of base pairs. Large repeats can also cause issues finishing a genome.

Your pay doesn't seem massively outside current industry norms.

If I were you I'd probably do two things:

1. I'd try and save enough money for a couple of years runway in case I wanted to do my own thing/start consulting.

2. I'd look around to see if there are other jobs that might be interesting. My biggest regrets are jobs I've stayed at too long, not the ones I left too quickly. Experience at many companies is great. Now, when you can take or leave a new job, is a good low stress time to look.

Not sure, but for me it's more that the selection is better, I don't think you can get Westworld (series) on amazon yet for example.

We don't really understand how most of the treatments we have work. We have data, we have in many cases some ideas, but we don't know.

Take Psoriasis as an example, doctors are still prescribing coal tar based treatments. I guess they are ~100 years old. They don't work very well, and people don't really know why they should work at all.

Pretty much all Psoriasis treatments are like this, even the more recent ones. They interfere with some pathway related to the immune system... but we don't really understand why they work.

So we don't really understand "how it all fits together" for current treatments. It's still reasonable to use them if they are relatively safe, and work. Same is true of gene therapies.

Mostly we figure out that things work/are safe through experimentation. Not through totally understanding the system.

Realistically, what harm can the experiments described in the article do to the general population?

It's so hard to do anything, even design diagnostic tests, that requires FDA approval that personally I'd avoid any startup that had that on their route to revenue.

It's kind of a shame, and countries where it's easier to develop new treatments and tests are likely to take the lead.

Why not use iTunes for pay per view/purchasing content? Their library seems very comprehensive.

I'm currently using Netflix and iTunes. I also have a prime account, but there's rarely anything I want to watch (the exception being Mr Robot).

Hmm.. this is significantly more than 100MUSD (630MUSD).

I'd love some examples of good plays in this area (that is, those that resulted not just in acquisition but viable products). This area being life science tools/diagnostics.

From the companies I've been it seems to be biased toward crazy plays that had a stack of money thrown at them. Honestly would like to hear about others, know where to read about others.

I'd love to have more insight into how this happened.

It seems like there's a pattern of high profile failures of highly funded science-based startups.

From the outside the science seems faulty from the start, the management team seems to have no strong scientific background.

Do investors really fund purely based on their force of personality? Personal connections? Do they see a big market and then ignore the scientific DD?

I'd love to understand this better.

Again, just FYI, you're not a PLC (which stands for public limited company, and means you can sell shares to the general public) you're incorporated as a private limited company.

Wow, I wouldn't be so confident in putting all this personal information out it the open. But this was a great read.

It's both sad, worrying, and slightly comforting that Mirai is run by a bunch of kids. Gives me hope that these issues can eventually be resolved.