botro

Thank you for sharing.

Thank you for sharing, the oncologists are saying that at this point in the diseases progression the same things that disqualify him from getting chemo also disqualify him from this drug. That in his current state it would do more harm.

I hope many others are helped by daraxonrasib, the key factor seems to be how early the cancer is detected, because it is an extremely fast acting disease.

My father in law was diagnosed with stage 4 pancreatic cancer that's spread to his lungs about a month ago. This news today raised my wife's hopes immensely and had them immediately doused after hearing the oncologist say that although the drug is approved it will take months before they are able to prescribe it.

Father in law started chemo a few weeks ago and his condition deteriorated quickly, he's been at the hospital since; switching between ICU and general care. His abdomen fills up with fluid, around 6 liters every 5 days, draining the fluid plunges his blood pressure and he end up in ICU. They supply Albumin until blood pressure stabilizes and send him back to general. Only after the first chemo session the oncologists have stopped the treatment saying he's no longer eligible for chemo because of his over all health.

We're lucky enough to live an hour away from Johns Hopkins (though that's not the hospital he's currently at) and had an appointment scheduled but had to cancel since he's unable to walk.

The oncologist mentioned that daraxonrasib was available as an option when he first started chemo, but said he would only be eligible for it after trying chemo, so we know the drug is available.

Are there any tips from HN on how we can approach getting this medicine for my father in law?

I wonder if LLMs modify their output when they realize they are interacting with a famous person.

By famous I mean someone whose biography is in the training data. All models know a lot more about Terrance Tao than they know about me, when he's working on his projects do the models know they don't need to explain "Besicovitch sets".

Since the system prompt likely includes something about not insulting the user, does the LLM modify it's responses if it realizes it's talking to famous politician, like "dont mention the time $politician was cancelled".

What are the challenges you've seen in selling air gapped? Is it the high upfront cost? Challenges with hardware maintenance or something else?

How about 'slippery incline'?

>On the insurance front - expect your insurance to decline this forever unless you are at serious risk of diabetes.

I'm not understanding this part. If these drugs have solved obesity and the whole host of associated diseases, including the number one killer; heart disease, shouldn't the insurance companies be clambering over each other to cover these drugs and heavily encouraging their use considering the cost reduction on the overall health system.

And if the incentives are misaligned with insurance companies why are governments not handing out GLP-1s to anyone who asks?

Is it known or suspected whether Shingrix offers the same benefits as Zostavax for dementia?

I've suffered from dry eyes for many years and have tried all the over the counter options available in the US with no success, especially for overnight dryness. Could you please share a hint for the Irish pharmacy delivering to the US?

I think that statista chart is month to month revisions, while the 900K figure is year over year, March 2024 to March 2025.

Yes, they put this in footnote 1: "Throughout this article “training” can refer to either pre-training, or fine-tuning." But the article is just talking about fine-tuning.

The International Space Station was an international effort by multiple (of the richest) countries specializing in different areas. There is no one country that does it all.

China built their own.