barake

What's preventing you from taking a GLP-1 with a BMI under 20? I started semaglutide with my BMI at 19.

Been on one for a few years now, it tempered my persistent auto-immune issues. Short term side effects are barely present for me. This stuff has made it so I don't have to be on steroids and antibiotics every other month. I did not start the medication for weight loss purposes, though have lost 10-15lbs, but I attribute that to being off steroids.

Long term? Who knows for sure. Semaglutide has been approved for 9 years. Liraglutide was 2009 and hasn't shown thyroid issues still. Exenatide has been available since 2005.

GLP-1s aren't new and haven't shown widespread negative issues beyond gastrointestinal upset, and that is typically fixed by... drinking more water. The trials in rats have pointed towards potential thyroid cancer risks but those haven't been seen in people.

That's one scenario. You can actually have sticky, engaged customers at huge scale, and even marginal profitability, while lacking Product-Market Fit. But breaking even/modest profits do not equal success for venture backed firms or mega-corps.

A good example is the voice assistant hardware from Amazon and Google. The speakers are everywhere, basic daily use stats are likely solid, and retail display square footage remains huge. Yet almost no one will pay for the associated subscriptions or other premium services. The hardware was sold at a loss(?) expecting downstream revenue from services that customers simply don't value enough to buy.

Anecdotally, it feels like Opus, Fable, and Sol "get distracted" when you use them for writing code. Great at reasoning and coordination but they will go off on a tangent and refactor half the code base. I only use them for reasoning (of course) and coordinating subagents.

Semaglutide does an incredible job of keeping my autoimmune issues in check. The only side effect I've had is needing to drink more water or else I feel like I've got the flu. Minimal tradeoff IMO

Apple TV is a little worrisome, surprised the A-series devices jumped so much. They're on older lines and have mostly been a way to recoup R&D for flagships. Theyre either subsidizing other products to soften the increase, or older process nodes are under serious demand suddenly.

Doesn't bode well for the industry. PlayStation and Xbox both switched to mostly-commodity hardware this gen and are years old, yet also facing the same price pressure apparently

It was sealed sets, still NIB, not individual pieces. No one would bother selling $200k of loose bricks on consignment.

If you use the product filter it only shows laptops that come pre-configured with 2TB of storage. If you choose a custom build you can configure the latest X1 Carbon with 32 GB RAM, 2 TB storage, and a 2.8k display.

If you choose the custom build route some even can ship with Fedora or Ubuntu, so presumably Linux support is reasonable.

Know some folks who used to work at Genscape. The whole business was selling live power generation data. They mostly accomplished it "hands-off" and without the permission of utilities.

If you had property adjacent to a power plant they would happily lease space to setup sensors.

Apparently there are tons of businesses like this gathering data that is mostly live and selling to hedge funds etc.