Recent submissions

Comment · 8 months ago
Less insulting than Macroslop
Comment · 2 years ago
My three-year-old daughter plays this with cat. It's a cross-species thing that is possibly part of mammalian brain development in origin.

The cat is less than one year old. Our 17 year old cat does not engage in this at all and hisses at the kitten for even trying to start a game of tag. This makes me wonder if that origin is more related to predator/prey.

Comment · 3 years ago
Now do United Health
Comment · 3 years ago
If it wasn’t for appearances only it would be under HR or perhaps HR would report into DEI role.
Comment · 3 years ago
They've given you a pull number and taken 'way your name
Comment · 3 years ago
It's doing what the voice assistants were supposed to: solve problems by assisting you with more context in a conversational manner.

Text to speech queries solve the problem of my hands being broken. ChatGPT solves the problem of my brain being contextually broken and I need more context, not higher relevant search results at the bottom of the screen after the ads that I then slog through to wind up changing my query and searching again like some sadistic freemium ad driven Sisyphean task that flies in the face of innovation to help me reach a contextual nugget.

Comment · 3 years ago
Nah, not even. I have a mutation called CDH1 that happens to be pathogenic and predisposes me to a greater than 40% chance of stomach cancer. It's a dominant gene which means it has a 50% chance I've passed it onto my daughter as well.

That cancer is what's known as a Hereditary Diffuse Gastric Cancer gene (HDGC). It just so happens that the E-cadherin control that suppresses those cancer cells is not processed properly. The diffuse part is what makes it particularly tricky. It's on the surface of the stomach epithelial cells and progresses from there. The only solution is a total gastrectomy (prophylactic if you do it early). No carcinogen necessary. It's found in populations all over the world and pathogenic lines don't even have to be related. The mutation can occur independently in the germline and is passed on. As long as you reproduce before it kills you nature really doesn't care.

Fun side fact. It also predisposes carriers to 70% chance of breast cancer. As a result many of those diagnosed are women who then find out they need to also have their stomachs removed.

Comment · 4 years ago
Have an endorsement!

"I've done 3 cross-country road trips and this captures everything I remember about Kansas excluding the IHOP in Wichita where we met an overworked waitress nearly running the entire place."

Comment · 4 years ago
If this pulled snapshots from Google street view for the car view it would be complete.
Comment · 4 years ago
I recall an Amazon director 10 years ago commenting during a mixer about how having kids was a limiting factor for career progression. It wasn’t possible to be serious about your career and be a parent.
Comment · 4 years ago
I climbed 40ft up the outside of a silo without a ladder. Kids do the dumbest shit.
Comment · 4 years ago
Fair, I know better, one of these days I’ll remember ;) Those are both the power numbers, not the generated numbers.
Comment · 4 years ago
Comment · 4 years ago
Time Division Multiplexing (TDM) was the weakest link in the land lines. Since so much traffic has moved off onto wireless I would think there's a lot of reason to use landlines as a reliable emergency line when the towers are overloaded or down. Landlines were reliable for power outages since the power was supplied separately by the phone company and the lines were buried in the ground.
Comment · 4 years ago
Agree.

A lot of this "controversial" stuff isn't ie therapeutic cures for sickle cell, a single nucleotide mutation with devastating impact on quality of life.

For some like myself with CDH1(https://en.wikipedia.org/wiki/CDH1_(gene)) it means a total gastrectomy is the prophylactic solution to avoiding hereditary diffuse stomach cancer. CDH1 is a more complex mutation than sickle cell.

These technologies are capable of doing more good than harm for society in the near term. The dystopian visions are not without merit, but that's the general rule of thumb for technology in general. A loss of genetic diversity is likely the gravest concern. Some mutations have benefit ie sickle cell vs malaria, but others like CDH1 have mostly been slipping under the evolutionary radar. There are multiple variants of concern and the mutation is just independently occurring across the global human population irrespective of any special heritage. There are other cancers/maladies just like this that medicine has no good solution for. They don't noticeably impede genetic reproduction so it carries from generation to generation.

For now most sane people are not considering germ-line modification. I would expect that to require multiple generations of study to even broach the subject.

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