SmellTheGlove

Its missing the wife/husband/child acceptance factor.

Yup, came here to say this. Once you're on the plane and its in the air, Spirit and Frontier are like pretty much every other domestic airline. There's slight variation in terms of whether you get a whole can of coke for free or not. If you're taller than me, the 28" of seat pitch vs say 31" on delta may make a difference, but I'm only 5'9".

I still avoided them like the plague because the legacy carriers are selling you operational performance and the ability to usually get you where you're going within a reasonable timeframe if you're delayed or canceled. Spirit, Frontier, Allegiant, whoever else, do not do nearly as good a job when something goes wrong. Although they should get a lot of credit - none of them have ever had a fatal crash.

It's not an either/or thing. At least for my kid, it's been a combination of the 3 that have helped, but if you dropped a component (including the medication), she wouldn't be doing nearly as well.

> It's certainly underdiagnosed in middle-aged women for example, and tends to be underdiagnosed in women in general.

What I'd like to see studied more is whether that root cause is underdiagnosis of inattentive type ADHD. My daughter was diagnosed because my wife is aware of this and had her evaluated, which led to me getting evaluated and eventually on medication. The common thread I've observed is that if you're reasonably intelligent such that it's not causing you to fail classes/get fired, people will just call you lazy and not entertain the idea that there's actually something else wrong. Couple that with girls/women having inattentive type w/o hyperactivity, and I think you do end up with a pretty solid bias.

> But also, ADHD meds are a complete lifeline when they work, and they do work in most cases.

For some there's a lot of trial and error, too. I wonder how many give up or insurance stops paying before they get to the right medication.

Yep, same, except I was like 40. Couldn't believe it took me that long.

Which drug are they on, if you're okay sharing?

I'm really glad to hear its going well for you! Her neurologist told us the achievable goal was to stop progression entirely. We were both surprised to hear that. She chose Tysabri because her brother has also had great results with it, and also because it mostly acts to keep your immune system outside the blood-brain barrier, rather than to target specific types of immune cells. Our understanding is you can basically stay on this until it stops being effective or you test positive for JCV exposure, at which point it's on to Ocrevus most likely.

If I can ask, what are you on now, and what happened that took you off of Tysabri? Feel free to not answer - it may be a bit sensitive to ask. I'm just trying to understand this all better since this is very new for my family.

The latter is my understanding.

It would be amazing if this type of treatment worked out. MS in particular seems to be a race between technology and your immune system. You hope the next cutting edge treatment is ready by the time the current state of the art stops working for you.

Yeah AHSCT is no joke. I mentioned in another comment my wife has MS - diagnosed last year in her mid 40s with thankfully no severe impairment. They discussed AHSCT with us but didn’t recommend it unless another disease modifying treatment didn’t work. Thankfully, Tysabri seems to be working well for her.

My mom passed from leukemia years ago. Or rather, from an infection as she was starting HSCT. I’m sure it’s safer than it was 30 years ago, but being without an immune system for a period of time really is still a last resort.

Glad to hear Ocrecus is working for you! My wife was diagnosed last year and has been on Tysabri for about 6 months. So far, so good. Having to go in for a monthly infusion isn’t something she loves, but zero side effects as of yet. Thankfully it’s a 1 hour infusion not 8.

Isn’t a dolly a flat 4 wheeled platform thingy? A hand truck is the two wheeled thing that tilts back.

It doesn't appear that they own it. More like they're adding infrastructure scaffolding to your project and giving you a CLI to deploy it. From what I can see, nothing breaks if you delete the CLI, and you're fine to deploy it to the same providers on your own or migrate it.

You know who is completely missing the boat on solving this problem? Heroku. I guess I should say Salesforce. It's pretty amazing though - they used to be the default "deploy this shit I just wrote" choice.

I'm excited to try Stripe Projects, but the thing I'm kind of dreading is the need for multiple providers. If I want auth, a database, and a front end, I'm using Supabase and Vercel, for instance. I don't blame Stripe for this - that's just where we're at right now, with everyone unbundling platforms over the past decade. I think platforms will be back in style soon enough.