RedditKon

We actually have a lot of data on Ozempic and GLP-1s generally, going back to the first GLP-1 FDA approval in 2005:

• Exenatide - FDA approved in 2005

• Liraglutide / Saxenda - FDA approved in 2010

• Dulaglutide / Trulicity - FDA approved in 2014

• Semaglutide / Ozempic/Wegovy - FDA approved in 2017

• Tirzepatide / Mounjaro - FDA approved in 2022

Ozempic / Semaglutide was FDA approved in 2017, but clinical trials started in 2008. That was 16 years ago. Obviously it's always possible there are even longer term side effects we're unaware of, but generally if this class of drug caused large scale problems for kidneys, liver, etc, we'd likely know by now.

Out of curiosity - what are you actually doing on these walks? You're talking outloud to yourself and then editing later or what?

How is copyright / licensing working on this site? Would love to learn!

Bc none of the features are actually live yet. We keep hearing about what will be released and demos - but HN is mainly do-ers. Their launches would have 100x the impact if people could see and play with it in real time right after the announcement.

Will they just be using Microsoft's offices?

If this is happening to you in California - look into California’s Amended Automatic Renewal Law that took effect on July 1, 2022.

SEO - Google ranks those pages higher.

How are you calculating the 2 years of runway?

Last I heard they have $1B in cash on hand and are doing roughly $3B/year in revenue. Musk has reportedly gotten their annual expenses down to $3B with another $1.5B in annual debt servicing costs.

By my math that's less than a year of runway.

Why do you define United as a cadillac plan? I've only had awful experiences with them thus far.

My guess is that they don’t want to cover a $1,000/month drug to save costs that you may not incur for many years / when you’re no longer insured by them.

It only works if all the companies agree to cover it.

Ozempic is widely available in Mexico (without prescription) and Canada (with prescription). It’s also available throughout Europe.

Mounjaro is not widely available outside the US yet.

100% this. A lot of people on Mounjaro report that one of the benefits is that their internal chatter about food / cravings is silenced. For the first time, when they get hungry they’re able to stop and consider whether they should eat a salad, reduce portion size, etc.

We already have it - you can buy Semaglutide easily on the clear net as it’s relatively easy / cheap to manufacture. r/peptides has more info.

Disclaimer: I’m not advocating this - just sharing info.