Pilottwave
Joined 6 years ago
Joined 6 years ago
Gemini output: Research is exploring nicotinic acetylcholine receptor (nAChR) agonists as a potential non-stimulant treatment for ADHD, sidestepping the issues of pure nicotine's high addiction liability.
The mechanism focuses on boosting dopamine (DA) and acetylcholine (ACh) release in brain areas governing attention and executive function, primarily by targeting the alpha4beta2 and alpha7 nAChR subtypes.
The goal is highly selective compounds that target the cognitive benefits (linked to alpha4beta2) while avoiding undesirable side effects and addiction pathways.
Selective alpha4beta2 Agonists (e.g., ABT-418, ABT-894/Sofinicline): These were developed to strongly activate the receptor most associated with DA release. Pilot and Phase II studies showed a signal of efficacy in adults with ADHD, with effect sizes similar to non-stimulant medications like atomoxetine.
Varenicline (Chantix/Champix): This is a partial alpha4beta2 agonist, FDA-approved for smoking cessation. Smaller trials suggested improvements in ADHD symptoms, but large-scale development for ADHD has been limited or terminated, and it is not approved for this indication.
Bupropion (Wellbutrin/Zyban): An established non-stimulant ADHD treatment (NDRI) and smoking cessation aid. While its main action is norepinephrine-dopamine reuptake inhibition, it also acts as a nicotinic receptor antagonist (blocking it), which is believed to help reduce nicotine craving. It is an approved non-stimulant option for ADHD.
I would love a simple mobile app, it's just easy to tap your news app on a phone, ideally with a way to customize the notification timing. I have certain moments each day when I want to consume this type of content (breakfast, lunch break)
A small community driven comment section with Karma system would also be nice. I like to discuss news and it enables knowledgeable people to add some additional insights. See the dutch tech news site for inspiration. they explain their karma system here: https://tweakers.net/info/faq/karma/#tab:1-2
Its been going on for some time. Something that was once a joke in good jest AKA Google's graveyard, is now their actual reputation, and helping their strong big tech competitors when competing on new services.
[email protected] Why wasn't Blockchain a watershed moment but chatGPT is.
There are several factors that contribute to why blockchain and chatGPT have had different impacts on their respective fields.
Firstly, blockchain technology has had a significant impact in certain areas, particularly in the financial industry, where it has been used to create new forms of digital currency and facilitate secure and efficient transactions. However, it has not yet achieved the widespread adoption and transformative impact that some had predicted. One reason for this may be that the technology is still relatively new and complex, and many organizations are still trying to figure out how best to implement it.
In contrast, chatGPT is a language model that has been designed to understand and generate natural language text. This technology has been more widely adopted because it has a broad range of potential applications, from customer service chatbots to language translation services. Additionally, language is a fundamental aspect of human communication, which makes the potential impact of language models like chatGPT more readily apparent to people.
Another factor that may have contributed to the different impacts of blockchain and chatGPT is the level of public attention and interest. While blockchain has received significant media coverage, it has not captured the popular imagination in the same way that chatGPT has. ChatGPT has been widely publicized and has even been featured in news articles and talk shows, which has helped to raise awareness and generate interest in the technology.
In conclusion, the differences in impact between blockchain and chatGPT can be attributed to a range of factors, including the complexity and novelty of the technology, the level of public awareness, and the broad range of potential applications.
My understanding is "tech enthousiast" level, so happy to learn.
I can also remind the old forum rules like: "No useless posts. This includes: Necroing, Thread bumping, useless one liners, Flamewars, Trolling and Spamming."
The above is no longer an issue in the more modern forum ranking methods in combination with nesting. Its frankly just sub-par any way you slice it, since the new ways have the features of the old and add to it. There is no regression only progress, you could argue.
Decentralized tech would never be where it is today if it weren't for investor attention and the potential for gains. We just have to separate the wheat from the chaff, and remain vigilant for bad actors.