Ezku

This wasn’t in the article, but I feel it makes for good background reading: “Universal Principles Justify the Existence of Concept Cells”, Scientific Reports 2020 (https://doi.org/10.1038/s41598-020-64466-7)

“Programming as Theory Building.” Peter Naur, Microprocessing and Microprogramming 1985 (https://doi.org/10.1016/0165-6074(85)90032-8)

> … suggests that programming properly should be regarded as an activity by which the programmers form or achieve a certain kind of insight, a theory, of the matters at hand. This suggestion is in contrast to what appears to be a more common notion, that programming should be regarded as a production of a program and certain other texts.

“Interpretation, Interaction and Reality Construction in Software Engineering: An Explanatory Model.” Kari Rönkkö, Information and Software Technology 2007 (https://doi.org/10.1016/j.infsof.2007.02.014)

> Floyd’s paper Outline of a Paradigm Change in Software Engineering requested that we move from a product oriented paradigm to a process oriented paradigm.

> Naur’s paper Programming as Theory Building made it painfully clear to us that exemplary resources in the form of material and available support are not enough when modifying others’ programs. In fact, if Floyd’s claims had been taken seriously by the software developers in Naur’s study, and if the same developers had access to an explanatory model … their difficulties could have been both anticipated and prevented.

> This article … explains from a natural language point of view, how interpretation takes place, and discusses the consequences of this in relation to interaction and reality construction in software engineering practice.

Braddy, Jon. “Utilizing the Octothorpe (#).” Exchanges: The Interdisciplinary Research Journal, April 2022. https://doi.org/10.31273/eirj.v9i2.837.

”Felix Guattari’s ‘Schizoanalytic Cartographies’ acts as a methodological blueprint and can be used to explain a subject’s lack of expressivity when confronted by Foucauldian systems of discipline and punishment. Understanding mechanisms of regulation and control within a closed or open system is the purpose of cybernetics. This communication studies tradition emerged from the artificial intelligence work of Norbert Wiener’s data flows with the intentional purpose of steering people, thought, societies, and the cosmos towards—becoming. Using the analogy of the octothorpe (#) as a roadmap explaining the four cartographies (Flows, Phyla, Territories, Universes) as outlined by Guattari, this manuscript will analyze the film, ‘War Games,’ demonstrating schizoanalytic technique. Another layer of power over humanity is not a panacea, rather it ushers forth civilisation’s speedier, and predicted, demise.”

Here’s also a web version of the PDF, as processed by Readwise Reader: https://readwise.io/reader/shared/01hjkgjb3qb9408fk8pg8xap3x

  > Consider valproic acid: For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds

  > Dimethyl sulfoxide (DMSO) is the most common organic solvent used in biochemical and cellular assays during drug discovery programs.
  > Despite its wide use, the effect of DMSO on several enzyme classes, which are crucial targets of the new therapeutic agents, are still unexplored.
  > 1-4% (v/v) DMSO, the commonly used experimental concentrations, showed ∼37-80% inhibition of human acetylcholine-degrading enzyme, acetylcholinesterase (AChE)

Oops! How many investigations on specific drugs were in fact showing mostly the results of what happens when interfering with one of the most ubiquitous-yet-underappreciated signalling systems, the cholinergic system?

I’m hoping widespread & systematic application of modern methods like in-silico molecular docking studies will lead to much fewer such oversights.

> A neuro-metabolic account of why daylong cognitive work alters the control of economic decisions. Curr Biol. 2022 https://pubmed.ncbi.nlm.nih.gov/35961314/

— Vitamin D and COVID-19: Role of ACE2, age, gender, and ethnicity. J Med Virol. 2021 https://pubmed.ncbi.nlm.nih.gov/33990955/

> Angiotensin-converting enzyme 2 (ACE2), a part of the renin-angiotensin system (RAS), serves as the major entry point into cells for SARS-CoV-2 which attaches to human ACE2, thereby reducing the expression of ACE2 and causing lung injury and pneumonia. Vitamin D, a fat-soluble-vitamin, is a negative endocrine RAS modulator and inhibits renin expression and generation… Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19.

— A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Rev Med Virol. 2020 https://pubmed.ncbi.nlm.nih.gov/32584474/

Here’s a caveat to remember when taking vitamin D:

> Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized … Mg is essential in the metabolism of vitamin D, and taking large doses of vitamin D can induce severe depletion of Mg. Adequate magnesium supplementation should be considered as an important aspect of vitamin D therapy.

— Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019 https://pubmed.ncbi.nlm.nih.gov/28471760/

> Because 5-HT cannot cross the blood-brain barrier, the peripheral 5-HT system is functionally separate from the central 5-HT system. — Diabetes Metab J. 2016 https://pubmed.ncbi.nlm.nih.gov/27126880/

https://github.com/iaolo/iA-Fonts/tree/master/iA%20Writer%20...

I would be really keen on seeing a mainstream-ish language that does algebraic effects or that can even implement them in a legitimate sense (discounting React’s implementation here, for instance). Purescript tried, but are doing something different these days. https://purescript-resources.readthedocs.io/en/latest/eff-to...