Abishek_Muthian
Joined 10 years ago
Karma
7,053
Submissions
2,625
Member since
May 26
Recent submissions
Comment · 21 hours ago
"Only those who do not seek power are qualified to hold it." - Plato
Comment · 3 days ago
I agree with your comment, I shouldn't have generalized all pharma. We also work with number of small pharma but the experience with big-pharma has been negative for rare-disease research and small-pharma are constrained in several ways.
I am not in U.S., but my govt. prefers to fund low hanging fruit w.r.t rare-disease i.e. those disease in which mechanistic details are clear and that has better probability of successful treatment; this ignores all those rare diseases which doesn't even have clear mechanistic details like GNE Myopathy.
After a long struggle, with help of corporate donors and a research institute we're now conducting a natural history study ourselves[1].
Comment · 3 days ago
My wife lives with a rare form of Muscular Dystrophy - GNE Myopathy. It's a progressive muscle wasting disorder, eventually she will be bed ridden. Her parents (prominent biologists themselves) have dedicated last 25 years of their lives trying to find a cure for her through conventional science in vain.
If the work by Cody Trangbarger pays off and some how helps find a cure or at least halt the muscle wasting of GNE patients, then I will start to believe that AI is truly revolutionary and not a hyped up normal technology.
Rare disease research have always suffered from lack of funding as pharma companies don't have incentive to find a cure for small numer of patients when there are easier ways to make money from diseases which affect larger populations.
Interestingly AI companies seem to be desperate to prove the usefulness of their product and so for the first time rare diseases are getting the spotlight, I hope this works as I live with a rare disease myself.
Comment · 14 days ago
I might have misunderstood your statement but I use rust all the time with dart FFI in my apps.
Comment · 14 days ago
I've been using layered development techniques like the parent says even with frontier models, just one agent at a time with Zed.
Comment · 14 days ago
Try to use your IGPU as well if you have enough RAM, almost everyone has dual GPUs in their computers.
Use Vulkan build of llama.cpp to run low parameter MoE models in your IGPU and CUDA llama.cpp to run dense models in your DGPU.
Ofcourse you need to set your expectations right on what problem you want to solve, I've not been happy with using quantized models for coding even on a decent laptop; where as for NLP, ASR, STT etc. work great with this setup.
I might write more about this setup soon.
Comment · 17 days ago
I'm 40; multiple disabilities due to a rare disease with no cure and neurodivergent. I live in a autocratic third-world country. I had to shutdown my startup for which I had put everything due to my health complications.
I was lost and didn't see any meaning to life, until;
I met this women, with a progressive muscle wasting rare-disease without cure which would eventually make her bed-ridden. Apart from regular work, she works day and night to help people with same disease as hers.
She's always jovial and never seen her complain. Watching her, my problems became minuscule. We fell in love and got married.
I have found my new meaning for life.
P.S. My username is my name, feel free to reach out.
Comment · 22 days ago
Doesn't supabase edge functions run on Deno? I presume this is huge setback for companies like that and their users.
But then again considering there's no barrier for entry to develop runtimes now, I guess these companies are just going to develop their own.
Congratulations to the Deno employees.
Comment · 26 days ago
I tried "write binary tree in rust and ensure it compiles with rustc" using the coder model with their chat it didn't produce the correct output and their chat can't call tools. Then with opencode it went on thinking loop until it exhausted the thinking budget.
4090 16gb, 96 gb RAM.
But I like this overall approach of neutering experts and loading them from ssd to make the model run in low VRAM systems.
Comment · 27 days ago
With limited VRAM, you can still use local LLMs but you have to set your expectations correctly to solve the right problem.
I run small models on various kind of devices including 1.7B model on the original Jetson Nano (4B) abandoned by Nvidia, I had to upscale the software (OS, Lllama.cpp etc.) to run the model but the model runs at 17t/s.
Small models are great at NLP stuff like classification (e.g. bookmarking), ASR etc. I have built custom browser extensions to save time with bookmarking and categorizing to use with local LLMs.
Comment · 2 months ago
LosslessCut is great, but I've had issues with the final export like timing being off, having cut sequence etc. I think it is very particular about encoding/container.
Shotcut is my default video editor, if anyone's trying it on Linux please use their AppImage as it solved most of my headaches when I was using Flatpak version.
Comment · 2 months ago
HF CEO keeps posting about how great local models are running in his Mac, it would be funny to see if he replaces his MacBook with a 500W Nvidia laptop after the deal gets through.
But more importantly for business, if HF fails to use the upcoming ASIC inference chips for their ZeroGPU after the acquisition, their competitors using them might have an advantage.
Comment · 2 months ago
At this point manufacturers should just open-source their firmwares as there's no barrier for entry to reverse engineer it. They will instead gain from army of end-users willing to put their time and tokens into fixing their bugs for free.
Comment · 2 months ago
After 3 years of running local models I think the model which fits unquantized (BF16) in the VRAM is the best model for general purpose tasks; fine-tuned SLMs or utilities based on non language models for solving a specific problem (e.g. TTS,STT,RMBG etc.) have been the best use of local AI for me.
Local models for coding, is just not worth the effort IMO; unless of course you have the hardware to fit it unquantized in your VRAM.
Comment · 2 months ago
One of the main features of Logi Options + is the plugins which this application doesn't seem to support; you can load it locally or from their marketplace[1].
I myself have an accessibility related plugin to make clicking easier [2] built using their Logi Actions SDK. It finds the clickable elements near the cursor and displays them in the Actions Ring and the LCD keypad. If you have the Logi Dialpad then you can have a complete mouse free workflow with Access Ring.
Website: abishekmuthian.com
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Building solutions to solve some health problems,
Bone Health Tracking - bonehealthtracker.com
Memory, lack of thereof - memoryhammer.com
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Building solutions to help create sustainable income for the indies - https://openpaymenthost.com
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Built a problem validation forum - needgap.com
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Built a tool-chain for startups - startuptoolchain.com
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Blog about indie business : hitstartup.com
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Before that founded Timebender Technologies Ind. Pvt. Ltd. and ran that for 5 years.
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I read HN on my Kindle, You can too: https://github.com/abishekmuthian/hntoebook
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Some need-gaps, which is related to discussions on HN:
(If you're interested in building a solution, know a solution or would like to have a solution please visit the respective problem thread)
Meta | Related HN comment id - https://news.ycombinator.com/item?id=26644616#26662755
#30 'Getting things done at individual level' https://needgap.com/problems/30 | Related HN comment id - https://news.ycombinator.com/item?id=28447499#28454477
#263 'Plan Second-Order, Third-Order consequences' https://needgap.com/problems/263 | Related HN comment id - https://news.ycombinator.com/item?id=28490755#28499423, 28106641
#234 'What has been removed due to chip shortage' https://needgap.com/problems/234 | Related HN comment id - https://news.ycombinator.com/item?id=28314072#28325194
#188 'Proving computer hack' https://needgap.com/problems/188 | Related HN comment id - https://news.ycombinator.com/item?id=29371088#29376646
#157 'Weekly review of high profile startup lawsuits' https://needgap.com/problems/157 | Related HN comment id -https://news.ycombinator.com/item?id=28338830#28370668
#241 'Search and organize saved reddit posts/comments' https://needgap.com/problems/241 | Related HN comment id - https://news.ycombinator.com/item?id=29217485#29225716
#57 'I forget my web bookmarks quite often.' https://needgap.com/problems/57 | Related HN comment id - https://news.ycombinator.com/item?id=29217485#29223442
#41 'Human memory, lack of thereof' https://needgap.com/problems/41 | Related HN commentid - https://news.ycombinator.com/item?id=29217485#29223442
#20 'Deep Fake video generating SW for ethical usage' https://needgap.com/problems/20 | Related HN comment id - https://news.ycombinator.com/item?id=28450783#28459765
#277 'What will be my AWS bill after free 12 months' https://needgap.com/problems/277 | Related HN comment id - https://news.ycombinator.com/item?id=29004934#29010606
#259 'Suggest unique pronounceable baby names' | https://needgap.com/problems/259 | Related HN comment id - https://news.ycombinator.com/item?id=29118785#29119840
#80 'Monetizing open-source projects' https://needgap.com/problems/80 | Related HN comment id - https://news.ycombinator.com/item?id=28692417#28715596
#251 'Eye strain due to lockdown' https://needgap.com/problems/251 | Related HN comment id - 28005144
#201 'Show meaning of words in a video' https://needgap.com/problems/201 | Related HN comment id - https://news.ycombinator.com/item?id=29085092#29092326
#274 'Single referral system for all services' https://needgap.com/problems/274 | Related HN comment id - 28004032
#141 'YouTube like public chat for ecommerce websites' https://needgap.com/problems/141 | Related HN comment - https://news.ycombinator.com/item?id=29823303#29848668
#49 'Password less authentication' https://needgap.com/problems/49 | Related HN comment id - 28071036
#12 'Identifying letter O from 0 and vice versa' https://needgap.com/problems/12 | Related HN comment id - 27984547
#279 'Better way to read twitter threads' https://needgap.com/problems/279-better-way-to-read-twitter-threads-twitter-reading | Related HN comment id - 28076504
#94 'Identifying gender from a name for marketing' https://needgap.com/problems/94 | Related HN comment id - 27958455
#284 'Online marketplace for hardware-tools in India' https://needgap.com/problems/284 | Related HN comment id - https://news.ycombinator.com/item?id=28194608#28198123
#149 'Remote education for underprivileged' https://needgap.com/problems/149 | Related HN comment id - 27911090
#269 'Keeping the things I like with me' https://needgap.com/problems/269 | Related HN comment id - 27874446
#42 'Identifying fake reviews in Amazon, other sites' https://needgap.com/problems/42 | Related HN comment id - 27864648
#156 'Get me the news I need, Not the news I want' https://needgap.com/problems/156 | Related HN comment id - 27673188
#102 'External storage with hardware compression' https://needgap.com/problems/102 | https://news.ycombinator.com/item?id=28395169#28407512
#59 'Notification Pollution' https://needgap.com/problems/59 | Related HN comment id - 27430593
#229 'Paywall avoidance for submission sites' https://needgap.com/problems/229 | Related HN comment id - 27247337
#6 'Safe, affordable and efficient mosquito control' https://needgap.com/problems/6 | Related HN comment id - 26921969
#207 'Search Engine Wall of Shame' https://needgap.com/problems/207 | Related HN comment id - https://news.ycombinator.com/item?id=28224730#28237342, 26859261, 26550907
#200 'Human voice summary of news' https://needgap.com/problems/200 | Related HN commend id - 26815657
#218 'Distributing computing loads across all devices' https://needgap.com/problems/218 | Related HN comment id - 26802803
#209 'Monitoring Interweb for leaked data' https://needgap.com/problems/209 | Related HN comment id - 26694613
#179 'Upload local music and sync playlist' https://needgap.com/problems/179 | Related HN comment id - 26682948
#198 'Hand wash liquid which doesn't make the skin dry' https://needgap.com/problems/198 | Related HN comment id - 26651051
#169 'Teach me vocabulary without spending extra time' https://needgap.com/problems/169 | Related HN comment id - 26607549, https://news.ycombinator.com/item?id=29085092#29092326
#144 'On-demand Hacker News notification' https://needgap.com/problems/144 | Related HN comment id - 26595123
#43 'Affordable E-Ink large external displays' https://needgap.com/problems/43 | Related HN comment id - 26532242
#51 'Non cellular network mobile Internet' https://needgap.com/problems/51 | Related HN comment id - 26378465
#196 'Reduce document file size to specific size' - https://needgap.com/problems/196 | Related HN comment id - 26325269
#64 "Make TV dumb again" - https://needgap.com/problems/64 | Related HN comment id - 26290660
#22 "Enabling hearing aid features on TWS earphones" - https://needgap.com/problems/22 | Related HN comment id -https://news.ycombinator.com/item?id=28391780#28401698, 26240299
#70 "Identifying myself from random Internet videos" - https://needgap.com/problems/70 | Related HN comment id - 26122623
#102 "External storage with hardware compression" - https://needgap.com/problems/102 | Related HN comment id - https://news.ycombinator.com/item?id=28395169#28407512
#229 'Paywall avoidance for submission sites' - https://needgap.com/problems/229 | Related HN comment id - https://news.ycombinator.com/item?id=28311728#28325367