Comment by scaturr

Yes. Absolutely. The library includes a blob() function for converting a watermarked image to a blob for use with FormData. The site has a demo that does just this for uploading to S3. Any browser supporting File API, FormData, and typed arrays should have no problems. IE 10 is the earliest IE that supports these APIs out of the box, but there are polyfills for IE9. The other modern browsers have supported these APIs for a while now.