Hm, sorry but ages of experience show that what mostly works is the other way around: You want to be a big city because you can find clients (users), meet people (e.g. possible investors) and generally speaking do any sort of networking that would be otherwise impossible.
The internet is what it is, but you can never match the face-to-face relationship with an online approach.
I totally understand that this is a dream-like situation: You make a good amount of money, doing what you like in a remote island where the sun shines and the food is always tasty (yes I'm from Greece...) but if your business can't be done 100% online, which is almost never the case, then you need offices in a big city. Then you need to visit and control these offices, etc.
The internet is what it is, but you can never match the face-to-face relationship with an online approach.
I totally understand that this is a dream-like situation: You make a good amount of money, doing what you like in a remote island where the sun shines and the food is always tasty (yes I'm from Greece...) but if your business can't be done 100% online, which is almost never the case, then you need offices in a big city. Then you need to visit and control these offices, etc.