I made a file tagging system with node-webkit and Vue (+ gulp/browserify/partialify). Vue was a joy to use. Most of the complexity in the app was dealing with sqlite, Sequelize and many-to-many relationships. Once the data got into a Vue VM it was smooth sailing.
I did run into some performance problems (rendering huge lists into complex tables), but I was able to iron them out for the most part. The only downside, which is definitely not unique to Vue, was debugging--a ton of functions get called in the Vue code when model data changes, so it can be tricky to find the right combination of breakpoints to set to track down why what you're expecting to happen isn't happening.
I did run into some performance problems (rendering huge lists into complex tables), but I was able to iron them out for the most part. The only downside, which is definitely not unique to Vue, was debugging--a ton of functions get called in the Vue code when model data changes, so it can be tricky to find the right combination of breakpoints to set to track down why what you're expecting to happen isn't happening.