I think this low-hanging-fruit idea is generally true for all of science: after centuries of science as a profession, pretty much all the easy stuff has already been done.
It's actually an argument for more cojones in science-- being willing to do bold stuff and explore "crazy" hypotheses. If all the easy stuff is done already, then picking methodically and timidly among the dregs is unlikely to ever yield anything.
It's actually an argument for more cojones in science-- being willing to do bold stuff and explore "crazy" hypotheses. If all the easy stuff is done already, then picking methodically and timidly among the dregs is unlikely to ever yield anything.