Comment by dbbolton

Side note: acetaminophen is a much bigger threat than most opioid analgesics themselves. It's directly involved in something like 10% of all overdoses in the US. There's no practical reason for opioids like hydrocodone to be mixed with it (as opposed to just being prescribed/administered concurrently) except that you get sick if you try to take enough of the opioid to get high. Personally, I feel that hepatotoxicity is a poor abuse deterrent, both in theory and practice.