Comment by jessaustin

I haven't had a spleen in over twenty years. In my experience, asplenia has not led to sickness any greater than the norm. I have kept up with recommended vaccinations, but I'm personally not a very "clean" person. I get sick a couple of times a year, which seems typical, and I've only been memorably sick a couple of times since I lost my spleen. Certainly you and others have different experiences. Perhaps your antibiotic requirements are more related to surgical wound healing?