25Y Male making over $250K+ annually. Still stuck. Help?

My friend is a 25Y old male with a wife and a newborn. He has a high paying salary (Over $160K+ annually), and his wife makes over $90K. His schedule is pretty flexible, and he enjoys his job although he hates his commute. They aren't a showy family. They both drive used cars, cook at home, max out their 401K, etc. However, my friend still feels "stuck". Like he hasn't accomplished what he was called to do in life. He's always working on some startup trying to become the next millionaire but continues to fail. What kind of advice can I give him?