Comment by pedrobeltrao

Protein folding is an interesting and computational challenging task. So challenging that some groups have sort of given up on it and move to other fields. Look up David Baker and Rosetta for more info. This is just an example, there are many many problems to work on. I feel sorry for the author of the post, bioinformatics is only getting more interesting as our capacity to make experimental measurements grow. There have been so many interesting findings that are just the product of bioinformaticians digging into existing databases and analyzing them to come up with new theories that have since then been experimentally validated.