> In this day and age, this shouldn't be an open question tbh.
Are you being paid by the Vitamin D council or something? I thought HN was about curious conversation.
> There is an extensive body of research, with dozens of meta-analysis / systematic reviews aiming to settle the score on this. If you let Claude or your favorite LLM du jour loose on Pubmed I'm sure it will surface some very reliable conclusions.
After I finished my degree in human nutrition, I decided to go to medical school because of the amount of free time I was spending on PubMed. I previously had high hopes for vitamin D, but I am now a skeptic specifically due to the dearth of rigorous and supportive studies on PubMed.
Do you have any favorite trials of exogenous supplementation that are in humans, large sample size, RTC with appropriate blinding, and have positive, meaningful / non-surrogate outcomes? This would seem easy to accomplish given its wide availability, low cost, and excellent safety margin.
Are you being paid by the Vitamin D council or something? I thought HN was about curious conversation.
> There is an extensive body of research, with dozens of meta-analysis / systematic reviews aiming to settle the score on this. If you let Claude or your favorite LLM du jour loose on Pubmed I'm sure it will surface some very reliable conclusions.
After I finished my degree in human nutrition, I decided to go to medical school because of the amount of free time I was spending on PubMed. I previously had high hopes for vitamin D, but I am now a skeptic specifically due to the dearth of rigorous and supportive studies on PubMed.
Do you have any favorite trials of exogenous supplementation that are in humans, large sample size, RTC with appropriate blinding, and have positive, meaningful / non-surrogate outcomes? This would seem easy to accomplish given its wide availability, low cost, and excellent safety margin.