tldr; No sane drug professionals would have designed a relatively simple compound (144 Atomic Mass) as a Multiple Sclerosis drug
I think human review may screw things up. If you look at dimethyl fumarate[1], no card carrying medicinal chemist would have taken this serious. No pharma exec would have risked 100s of millions of dollars for clinical research trials.
- 1950s people notices that a wood polish cleared psoriasis. Topical formulation worked.
- 1990s an oral formulation was created.
- 2000s people noticed people treated for psoriasis that had MS, had fewer MS symptoms while taking this molecule.
- 2017 dimethyl fumerate is approved for MS.
[1] https://en.wikipedia.org/wiki/Dimethyl_fumarate
I think human review may screw things up. If you look at dimethyl fumarate[1], no card carrying medicinal chemist would have taken this serious. No pharma exec would have risked 100s of millions of dollars for clinical research trials.