Comment Comment by a_bonobo and we do know that cholesterol build-up is linked with reduced mobility:'Late endocytic vesicles loaded with cholesterol lose their dynamic properties, and become essentially immobile'https://link.springer.com/article/10.1093/emboj/21.6.1289we also know that blocking cholesterol in viruses leads the cholesterol-stuffed lysosomes to recruit DCTN1https://www.nature.com/articles/s41467-024-50711-4but I can't find anything that links a DCTN1 downregulation directly - as you say, this is a hypothesis a PhD student comes up with during literature review. parent a_bonobo 11 days ago
'Late endocytic vesicles loaded with cholesterol lose their dynamic properties, and become essentially immobile'
https://link.springer.com/article/10.1093/emboj/21.6.1289
we also know that blocking cholesterol in viruses leads the cholesterol-stuffed lysosomes to recruit DCTN1
https://www.nature.com/articles/s41467-024-50711-4
but I can't find anything that links a DCTN1 downregulation directly - as you say, this is a hypothesis a PhD student comes up with during literature review.