Comment by robwwilliams

This is true, but perhaps not for the reason you have in mind. The “failures” are exaggerated by shoddy experimental design—mainly trying to generalize from a single fully inbred strain of mouse. Most murine research is based on this one strain: C57BL/6. This is like conducting a clinical study with one seriously inbred human subject multiple times. Very poor generality even to other types of mice, let alone to humans.