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Comment by graeme

There is another plausible causal mechanism: weight gain flowing from hunger/metabolic dysregulation. This dysregulation being caused by some "factor X" which also causes other problems.

GLP-1 then addresses factor X, and the problems it causes, including weight gain.

Not that obesity doesn't independently cause problems but very plausible causality runs more than one way.

parent graeme 17 days ago

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