The only proper answer is retroactive bans (a-la competitive doping: "retrospective testing").
Cheaters (athletes) are always incentivized to cheat in "new and exciting ways" today. It's impossible to defend against all possible new forms of cheating, but they instead keep blood samples for up to ten years so that "when they figure out what to test for", they can retroactively penalize participants.
Same with online cheating, save high fidelity recordings and be able to replay. As detection catches up to exploitation, you ban hammer the prior exploiters.
Cheaters (athletes) are always incentivized to cheat in "new and exciting ways" today. It's impossible to defend against all possible new forms of cheating, but they instead keep blood samples for up to ten years so that "when they figure out what to test for", they can retroactively penalize participants.
Same with online cheating, save high fidelity recordings and be able to replay. As detection catches up to exploitation, you ban hammer the prior exploiters.