You know I took the wrong conclusions from frog/rat developmental studies in space. As far as I can tell low gravity isn't known to be a killer, just that the whole process hasn't been studied (no mammal recorded to give birth in space).
As to whether or not that makes Mars hard, I think it doesn't matter how well you can control the climate if you can't have a second generation of people to live there.
As to whether or not that makes Mars hard, I think it doesn't matter how well you can control the climate if you can't have a second generation of people to live there.