Comment by OutOfHere

Isolated fructose and its derivatives, e.g. HFCS, don't sufficiently trigger satiety, while stressing the liver and the heart. In contrast, regular sugar and glucose trigger satiety. This has been known for over a decade.

For anyone who actually bothers to read:

https://medicalxpress.com/news/2026-06-fructose-weaker-satie...

https://medicalxpress.com/news/2014-12-brain-reward-circuits...

https://medicalxpress.com/news/2015-06-fructose-brain-reward...