Wow I had never heard of this whistleblower guy Tyler, this email is honestly amazing.
> In my meetings with Daniel I found that the discrepancies between our CVs were due to Daniel calculating CV based on the median value of each precision run, while I was calculating CV of the entire data set for each level. When I asked him why we do this, he said that it was a way to average out the noise. I was under the impression that the coefficient of variation was meant to be, at least in part, a measure of how much noise exists in the data. By averaging out this noise before CV is calculated, the CV as a metric of assay performance becomes less meaningful.
“Becomes less meaningful”… this is the most polite way I can imagine telling your CEO, “hey, our results are all BS”. His message is so thorough and measured, and they just tear into him. He’s the only professional in the room.
> In my meetings with Daniel I found that the discrepancies between our CVs were due to Daniel calculating CV based on the median value of each precision run, while I was calculating CV of the entire data set for each level. When I asked him why we do this, he said that it was a way to average out the noise. I was under the impression that the coefficient of variation was meant to be, at least in part, a measure of how much noise exists in the data. By averaging out this noise before CV is calculated, the CV as a metric of assay performance becomes less meaningful.
“Becomes less meaningful”… this is the most polite way I can imagine telling your CEO, “hey, our results are all BS”. His message is so thorough and measured, and they just tear into him. He’s the only professional in the room.