Comment by neobrain

Even for pure research/prototyping, you quickly run into the problem that your sandbox is either prohibitively minimal or overly permissive. Depending on the exact task, you may need GPU access, Docker/Nix socket access, ability to ptrace processes (gdb), run webfetches, etc. If I define a "research" sandbox profile to allow all of these, I might as well not have any sandbox at all.