Not the GP poster, but some answers:
> Does SV40 cause cancer?
Yes, in a range of animal models at least.
SV40 can 'immortalise' cells, turning off regulatory functions which prevent uncontrolled division, which is an important part of carcinogenesis. This has been shown to contribute to cancer in experimental systems.
> Did and does SV40 inadvertendly inside the Polio Vaccine in the late 1950ies and 60ies cause cancer?
The evidence suggests not significantly, although it's impossible to rule out for some unlucky individuals.
The SV40-exposed cohorts rates of cancers don't differ that greatly from unexposed groups, so we can say with certainty that the rate is much less in humans than seen in laboratory systems. There were suggestions of differences for some cancers, but these are heterogeneous and often confounded, and the general consensus now seems to be the effect was small if not zero. I don't think there's a definitive answer on why - possibly the exposure was sufficiently low or the virus was not effective at infecting humans to significantly affect the carcinogenic processes.
> Does the Pfizer proces 2 SV40 promotor in the Covid Vaccine cause cancer?
Certainly not by the mechanism intact SV40 causes cancer.
That depends on the production of particular SV40 proteins which interfere with cell functions, which aren't present in that promoter.
> Does DNA contamination in general cause cancer?
In general, no.
Cells are constantly exposed to both native and foreign DNA fragments, and have plenty of mechanisms for dealing with them. Even if fragments were somehow incorporated and expressed, most are not inherently carcinogenic.
> Does SV40 cause cancer?
Yes, in a range of animal models at least.
SV40 can 'immortalise' cells, turning off regulatory functions which prevent uncontrolled division, which is an important part of carcinogenesis. This has been shown to contribute to cancer in experimental systems.
> Did and does SV40 inadvertendly inside the Polio Vaccine in the late 1950ies and 60ies cause cancer?
The evidence suggests not significantly, although it's impossible to rule out for some unlucky individuals.
The SV40-exposed cohorts rates of cancers don't differ that greatly from unexposed groups, so we can say with certainty that the rate is much less in humans than seen in laboratory systems. There were suggestions of differences for some cancers, but these are heterogeneous and often confounded, and the general consensus now seems to be the effect was small if not zero. I don't think there's a definitive answer on why - possibly the exposure was sufficiently low or the virus was not effective at infecting humans to significantly affect the carcinogenic processes.
> Does the Pfizer proces 2 SV40 promotor in the Covid Vaccine cause cancer?
Certainly not by the mechanism intact SV40 causes cancer.
That depends on the production of particular SV40 proteins which interfere with cell functions, which aren't present in that promoter.
> Does DNA contamination in general cause cancer?
In general, no.
Cells are constantly exposed to both native and foreign DNA fragments, and have plenty of mechanisms for dealing with them. Even if fragments were somehow incorporated and expressed, most are not inherently carcinogenic.