px is still a useful unit. the user's operating system applying a scaling fator doesn't make it not useful.
if the user's operating system is configured to draw pixels at a 1:1 ratio, your pixels will be drawn at a 1:1 ratio. if the user's operating system is configured to draw pixels at a 2:1 or 3:1 ratio, you as a web developer don't get to override that, but you're still addressing pixels directly. if you want to write software that manages the user's hardware directly without giving them options to override it, the web is probably not the right platform for you.
if the user's operating system is configured to draw pixels at a 1:1 ratio, your pixels will be drawn at a 1:1 ratio. if the user's operating system is configured to draw pixels at a 2:1 or 3:1 ratio, you as a web developer don't get to override that, but you're still addressing pixels directly. if you want to write software that manages the user's hardware directly without giving them options to override it, the web is probably not the right platform for you.