A lot of metabolic stuff is due to insulin and insulin sensitivity. This drives pretty much everything. Insulin sensitization is pretty terrible and it gets more important as you age.
Unfortunately natural selection doesn't need to fix this as it doesn't cause issues until after reproduction and often until after your grandkids are born.
Semaglutide and glp1s resensitize it which is why they have these effects.
Semaglutide and glp1s resensitize it which is why they have these effects.
My opinion