I am aware, I personally knew someone who did so a decade ago. This is very different from synthesizing and culturing a virus from a sequence. Also, you wouldn't use CRISPR for this, you'd make a plasmid.
The best defense for these is upstream, so that the plasmid provider refuses to make it for you if it looks like a pathogen or you're not affiliated.
The best defense for these is upstream, so that the plasmid provider refuses to make it for you if it looks like a pathogen or you're not affiliated.