There is really no good reason to ever use I2C, except if that's the only interface your peripheral supports. Debugging a stuck I2C bus, and attempting to un-brick the bus for a stuck slave (disabling ISRs, unhooking DMA, reconfiguring pins to GPIO, clocking the slave out of its coma and then doing everything in reverse) is just not worth it.
EDIT: I was hoping for HaLow WiFi!