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Comment by einhard
I am certainly no expert in this space so it is quite possible I'm missing something critical, but what seems to work for me is a Podman image I built on my computer with some basic things I need (using OpenCode, but I imagine any other agent could be used instead):
From there I just run the Podman image from the command line (using a Fish function) that mounts the specific project I'm working on to /workspace. I guess there might be some vulnerabilities with shared kernels and such, but it seems like an easy way to have some isolation.