Comment by twright

I think it would be hard not just because of the amount of variables you have to model for but mainly it just might not be fun--or the fun would be very niche. In "Oxygen Not Included", maybe the most Biosphere 2-like game, your colony quickly collapses if you welcome too many duplicants (people). If you do manage to balance that there are dozens of other ways for the colony to suddenly collapse but then it can be difficult to narrow down what decision(s) lead to it.