I've made games in Löve and with straight Python and it's always a lot of fun...though challenging at times.
Where I tend to struggle is with the overall game structure. Without being an actual professional programmer (nevermind a game programmer), I'm always wrestling with how to design the code structure in a way that is logical and professional. Leveraging common game design patterns isn't at all straight forward for a person like me.
Here are two resources I found quite helpful...
https://gameprogrammingpatterns.com/
https://refactoring.guru/design-patterns