With Windows in particular, you absolutely can navigate Windows + Office keyboard only. I do it every day.
Now, third party software, is always going to be all over the place. Stuff that was largely built on Win32 components works fine, but "modern" stylized applications rarely have strong support.
Now, third party software, is always going to be all over the place. Stuff that was largely built on Win32 components works fine, but "modern" stylized applications rarely have strong support.