I think a lot of it is down to Windows, not Prism itself.
For decades, Windows made it too easy for games and even some application to install drivers. Windows games use drivers for anti-cheat (and historically for copy protection too). Neither Apple Rosetta nor Microsoft Prism can translate/emulate drivers, but since drivers have been much more prevalent on Windows, now Windows has a much biggest compatibility problem.
For decades, Windows made it too easy for games and even some application to install drivers. Windows games use drivers for anti-cheat (and historically for copy protection too). Neither Apple Rosetta nor Microsoft Prism can translate/emulate drivers, but since drivers have been much more prevalent on Windows, now Windows has a much biggest compatibility problem.