Can it still? IIRC Guix still has GNOME 48 while GNOME said they'll be increasing they dependence on systemd after version 49 or 50[1]. I'd be happy if Guix can support future version as this seems like an end game distro for me, and I'm (slowly) looking into moving there but my understanding is I'd need to stay with KDE Plasma in the long-term.
[1] https://lwn.net/Articles/1025560/