I've been using ETP plus adblock-rs in Waterfox for 2 weeks. I don't see much a difference compared to ETP + ublock origin apart from some cosmetic filtering. The fact that it's not an extension supposedly allows to block at more layers so it's theoretically better than an extension (https://github.com/BrowserWorks/waterfox/issues/4182)
Note that there are (were?) also some small bugs in the waterfox integration (such as the configuration options sometimes disappearing).
Note that there are (were?) also some small bugs in the waterfox integration (such as the configuration options sometimes disappearing).