I've been getting lots of refusals by Codex with GPT 5.5 for "biosafety reasons" when asking for harmless things like code to analyze SARS-CoV-2 sequences for breakpoints. That's in no way useful for creating viruses whatsoever - it's pure research.
It's annoying that the refusal is so obviously false positive.
It's annoying that the refusal is so obviously false positive.