I have high cholesterol, have had for more than a decade. Was on a statin, they didnt help. Doubled them, they didnt help. Changed my diet radically, lost 25 lbs (I was a little overweight, but not bad), ate full medeteranian diet and did everything I could, my numbers didnt budge. Changed to a stronger one and within two weeks my numbers were perfect.
I believe for some of us its purely genetic.