The giant bugbear in this conversation is always multiplayer. That's because almost all of the big players in that space currently favor rootkits in the form of overly invasive anti-cheat, which the Linux wrappers (mostly the wine project) refuse to support for security reasons.
If you don't play PvP specifically, the rest of the library is significantly more open to you. Personally I have always favored single player experiences and indie games from smaller studios, and for the most part those run great.
If you don't play PvP specifically, the rest of the library is significantly more open to you. Personally I have always favored single player experiences and indie games from smaller studios, and for the most part those run great.