Comment by Konnstann

The immune response to diseases has to be developed over time, not to mention the fact that the introduction of those drugs drastically accelerated the evolution of the bacteria, viruses, etc. I can't speculate as to the health of hunter gatherer civilizations but modern diets and until recently the prevalence of antibacterial soaps and products in homes have definitely changed immune systems. Just look at covid, where in just a period of a few years the amount of infections due to other common diseases like influenza or strep have shot up due to kids not being exposed to germs during the lockdowns.